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NTP CHEMICAL REPOSITORY
P-PHENETIDINE


-IDENTIFIERS
===========

*CATALOG ID NUMBER: 001591

*CAS NUMBER: 156-43-4

*BASE CHEMICAL NAME: PHENETIDINE,P-

*PRIMARY NAME: P-PHENETIDINE

*CHEMICAL FORMULA: C8H11NO

*STRUCTURAL FORMULA:

*WLN: Not available

*SYNONYMS:
  PARA-AMINOETHOXYBENZENE
  4-AMINOETHOXYBENZENE
  PARA-PHENETIDINE
  ANILINE, P-ETHOXY-
  4-ETHOXYANILINE
  P-AMINOPHENETOLE
  PHENETHIDINE
  P-PHENETIDIN


-PHYSICAL CHEMICAL DATA
======================

*PHYSICAL DESCRIPTIONS:  LITERATURE:  Colorless liquid
                        REPOSITORY:  Dark red liquid

*MOLECULAR WEIGHT: 137.18

*SPECIFIC GRAVITY: 1.0652 @ 16/4 C

*DENSITY: Not available

*MP (DEG C): 2-4 C

*BP (DEG C): 250 C

*SOLUBILITIES:
      WATER : 5-10 mg/mL @ 20 C (RAD)

        DMSO : >=100 mg/mL @ 20 C (RAD)

95% ETHANOL : >=100 mg/mL @ 20 C(RAD)

    METHANOL : Not available

    ACETONE : >=100 mg/mL @ 20 C (RAD)

    TOLUENE : Not available

OTHER SOLVENTS: Not available

*VOLATILITY:
    Vapor pressure: 3.48 mm Hg @ 25 C
    Vapor density : 4.73

*FLAMMABILITY(FLASH POINT):
  The flash point of this compound is 115 C (240 F).  It is combustible.
  Fires involving this material can be controlled with a dry chemical, carbon
  dioxide or Halon extinguisher.

*UEL: Not available                        LEL: Not available

*REACTIVITY:
  This compound reacts vigorously with powerful oxidizers.  It turns red to
  brown on exposure to light and air.

*STABILITY:
  This compound is very sensitive to exposure to air and light.

*OTHER PHYSICAL DATA:
  Refractive index:  1.5528 @ 20 C
  pKa:  5.25


-TOXICITY
========

*NIOSH REGISTRY NUMBER: SI6465500

*TOXICITY: (abbreviations)
  typ. dose      mode    specie    amount      unit        other
      LD50          orl        rat        580      mg/kg
      LCLo          ihl        rat        250      mg/m3
      LD50          orl        mus        530      mg/kg
      LD50          ipr        mus        692      mg/kg

*AQTX/TLM96: Not available

*SAX TOXICITY EVALUATION:
  THR:  HIGH via inhalation route.  MODERATE via oral and unknown routes.

*CARCINOGENICITY: Not available

*MUTATION DATA:
      test          lowest dose              test          lowest dose
    ----------    ----------------    |    ----------    ----------------
  Not available

*TERATOGENICITY: Not available

*STANDARDS, REGULATIONS & RECOMMENDATIONS:
  OSHA: None
  ACGIH: None
  NIOSH Criteria Document: None
  NFPA Hazard Rating: Health (H): 2
                      Flammability (F): 1
                      Reactivity (R): 0
  H2: Materials hazardous to health, but areas may be entered freely with
      full-faced mask self-contained breathing apparatus which provides
      eye protection (see NFPA for details).
  F1: Materials that must be preheated before ignition can occur (see NFPA
      for details).
  R0: Materials which are normally stable even under fire exposure conditions
      and which are not reactive with water (see NFPA for details).

*OTHER TOXICITY DATA:
  Skin and Eye Irritation Data:
    skn-rbt  500 mg MLD
    eye-rbt  100 mg MOD
    eye-rbt  100 mg/4S rns MLD
  Standards and Regulations: DOT-IMO: Poison B; Label: St. Andrews Cross
  Status: Reported in EPA TSCA Inventory, 1983


-OTHER DATA (Regulatory)
=======================

*PROPER SHIPPING NAME (IATA): Phenetidines

*UN/ID NUMBER: UN2311

*HAZARD CLASS: 6.1          SUBSIDIARY RISK: None    PACKING GROUP: III

*LABELS REQUIRED: Keep away from food

*PACKAGING: PASSENGER: PKG. INSTR.: 611, Y611      MAXIMUM QUANTITY: 60 L, 2 L
            CARGO    : PKG. INSTR.: 618            MAXIMUM QUANTITY: 220 L

*SPECIAL PROVISIONS: None

*USES:
  Dyestuff intermediate; pharmaceuticals; laboratory reagents.


-HANDLING PROCEDURES
===================

*ACUTE/CHRONIC HAZARDS:
  This compound is toxic by ingestion, inhalation and skin absorption.  It may
  cause irritation on contact.  When heated to decomposition it emits toxic
  fumes.

*MINIMUM PROTECTIVE CLOTHING: Not available

*RECOMMENDED GLOVE MATERIALS: Not available

*RECOMMENDED RESPIRATOR:
      Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.

*OTHER: Not available

*STORAGE PRECAUTIONS:
      You should protect this chemical from exposure to light.  Keep
the container tightly closed under an inert atmosphere, and store
under refrigerated temperatures.  STORE AWAY FROM SOURCES OF IGNITION.

*SPILLS AND LEAKAGE:
      If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION.  Then,
use absorbent paper to pick up all liquid spill material.  Your contaminated
clothing and absorbent paper should be sealed in a vapor-tight plastic bag for
eventual disposal.  Solvent wash all contaminated surfaces with 60-70% ethanol
followed by washing with a soap and water solution.  Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.

*DISPOSAL AND WASTE TREATMENT:
Not available


-EMERGENCY PROCEDURES
====================

*SKIN CONTACT:
      IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing.  Gently wash all affected skin areas thoroughly
with soap and water.
      If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.

*INHALATION:
      IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
      Provide proper respiratory protection to rescuers entering an unknown
atmosphere.  Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.

*EYE CONTACT:
      First check the victim for contact lenses and remove if present.  Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
      Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
      IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.

*INGESTION:
      DO NOT INDUCE VOMITING.  If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center.  Be prepared to transport the victim to a
hospital if advised by a physician.
      If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body.  DO NOT INDUCE VOMITING.  IMMEDIATELY transport
the victim to a hospital.

*SYMPTOMS:
  Symptoms of exposure to this compound may include cyanosis, hypothermia, head-
  ache, drowsiness, vomiting, nephritis and irritation of the alimentary tract.


-SOURCES
=======

*SOURCES:
Hazards Research Corporation.  Vapor Pressure Determinations for
    Fifteen Materials:  HRC Report 5913D.  August 14, 1985.

Bretherick, L., Ed.  Hazards in the Chemical Laboratory.  3rd Ed.
    The Royal Society of Chemistry.  London.  1981.  p. 321.

Windholz, M., Ed.  The Merck Index.  10th Ed.  Merck and Co.
    Rahway, NJ.  1983.  p. 1040, #7097.

Sax, N.I.  Dangerous Properties of Industrial Materials.  6th Ed.
    Van Nostrand Reinhold.  New York.  1984.  p. 2158.

Occupational Health Services, Inc.  Hazardline.  Occupational
    Health Services, Inc.  New York.  1983.  Listed.

Aldrich Chemical Company.  Aldrich Catalog/Handbook of Fine
    Chemical.  Aldrich Chemical Co., Inc.  Milwaukee, WI.
    1984.  p. 865, #P1,481-5.

Weiss, G., Ed.  Hazardous Chemicals Data Book.  Noyes Data
    Corporation.  Park Ridge, NJ.  1980.  p. 1130.

Occupational Safety and Health Administration.  Tentative
    OSHA Listing of Confirmed and Suspected Carcinogens by
    Category.  Occupational Safety and Health Administration.
    Washington, DC.  1979.  Listed.

Oak Ridge National Laboratory.  Environmental Teratogen Information
    Center (ETIC), Bibliographic Data Base.  Oak Ridge National
    Laboratory.  Oak Ridge, TN.  Not listed.

Oak Ridge National Laboratory.  Environmental Mutagen Information
    Center (EMIC), Bibliographic Data Base.  Oak Ridge National
    Laboratory.  Oak Ridge, TN.  Not listed.

U.S. Environmental Protection Agency, Office of Toxic Substances.
    Toxic Substances Control Act Chemical Substances Inventory,
    Initial Inventory.  6 Vols.  U.S. Environmental Protection
    Agency.  Washington, D.C.  1979.  Listed.

Hawley, G.G., Ed.  The Condensed Chemical Dictionary.  10th Ed.
    Van Nostrand Reinhold.  New York.  1981.  p. 795.

Buckingham, J., Ed.  Dictionary of Organic Compounds.  5th Ed.
    Chapman and Hall.  New York.  1982.  Vol. 3, p. 2492, #E-00541.

Weast, R.C. and M.A. Astle, Eds.  CRC Handbook of Chemistry
    and Physics.  63rd Ed.  CRC Press, Inc.  Boca Raton, FL.
    1982.  p. C-428, #10740.

Lewis, R.J., Sr. and R.L. Tatken, Eds.  Registry of Toxic Effects
    of Chemical Substances.  Microfiche Ed.  National Institute for
    Occupational Safety and Health.  Cincinnati, OH.  Quarterly
    Updates.  SI6465500.

[610] Clansky, Kenneth B., Ed.  Suspect Chemicals Sourcebook:  A Guide to
          Industrial Chemicals Covered Under Major Federal Regulatory and
          Advisory Programs.  Roytech Publications, Inc.  Burlingame, CA.
          1990.  Section 3, p. 61.

[620] United States National Toxicology Program.  Chemical Status Report.
          NTP Chemtrack System.  Research Triangle Park, NC.  November 6, 1990.
          Not listed.

        -------------------------------------------------------------


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